The Patient-Centered Outcomes Research Institute (PCORI) is an independent, nonprofit research organization that seeks to empower patients and others with actionable information about their health and healthcare choices. We fund comparative clinical effectiveness research (CER), which compares two or more medical treatments, services, or health practices to help patients and other stakeholders make better informed decisions.

PCORI’s unique place in the health research landscape stems from its unwavering focus on outcomes that matter to patients and it is widely acknowledged as a leader in driving US clinical research to become more patient-centered. We are committed to ensuring that patients and other healthcare stakeholders have a seat at the table throughout the research process—helping to prioritize research topics, design and conduct the studies, and share the results.

The vast majority of the research that PCORI funds is for CER projects, but we also fund awards to promote engagement in research, dissemination and implementation projects, methodology research, and the development of research infrastructure, including PCORnet®, the National Patient-Centered Clinical Research Network. We issue PCORI Funding Announcements several times each year.