The Patient-Centered Outcomes Research Institute, or PCORI, is a nonprofit research funding organization that seeks to equip patients and those who care for them with actionable information to weigh the trade-offs of health and healthcare choices and make informed decisions that reflect their needs and preferences. PCORI funds patient-centered comparative clinical effectiveness research, or CER. This is research that compares the benefits and potential harms of established or broadly used treatments, clinical interventions or healthcare approaches to provide evidence that patients and other health decision makers can use. PCORI emphasizes the engagement of patients, caregivers and the broader healthcare community in all aspects of PCORI-funded research and research-related activities, including the dissemination and uptake of research findings