Cancer, now the top cost driver for employers/purchasers, is in the spotlight as trends shift. Inexplicably, more young people are getting cancer; medical professionals are struggling to keep pace with innovations; and, over the past five years, prices for new cancer drugs increased 53%. This session sets forth proven strategies that turbocharge prevention and early detection efforts; improve patient experience and quality of life; address health equity challenges; and manage treatment costs, alternative funding programs, and productivity.